Diagnostic Marker And Therapeutic Target For Ewing’s Sarcoma
ID U-4178
Category Diagnostics
Subcategory Biomarkers
Researchers
Brief Summary
Highly specific gene-based biomarker for the diagnosis of Ewing’s sarcoma.
Problem Statement
Ewing’s Sarcoma is an aggressive and highly metastatic bone or soft tissue associated tumor in children and young adults. These tumors frequently progress undetected until they metastasize, whereupon the mortality of the disease greatly increases. Identifying Ewing’s tumors typically involves detection of CD99 and EWS/FLI expression that have limited sensitivity and specificity.
Technology Description
Gene ontology (GO) analysis and subsequent studies in tumor tissues has verified NKX2.2 gene or protein expression as an important contributor to the neural characteristics of the tumor. The invention describes a quantitative approach to measuring NKX2.2 expression as a sensitive approach to diagnosing Ewing’s tumors. Additional biology studies have shown that blocking NKX2.2 expression causes Ewing’s Sarcoma cells to lose their oncogenic phenotype, which suggests additional therapeutic applications.
Stage of Development
Proof of Concept
Benefit
- Early biomarker for detection of Ewing’s sarcoma.
- Rapid and sensitive qPCR-based test.
- Can be added to other gene panels for multiplex testing for other biomarkers or cancer types.
Publications
Fadul, J., Bell, R., Hoffman, L.M., Beckerle, M.C., Engel, M.E., Lessnick, S.L. (2015). EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes & Cancer. 6(3-4): 129-143. doi: 10.18632/genesandcancer.57
IP
Publication Number: US-2008-0280844-A1
Patent Title: Methods and Compositions for the Diagnosis and Treatment of Ewing's Sarcoma
Jurisdiction/Country: United States
Application Type: Non-Provisional
Contact Info
Aaron Duffy
(801) 585-1377
aaron.duffy@utah.edu