Genetically modified bacteria with eukaryotic quinic acid regulatory system produces ~2.5 times more recombinant protein.

Obtaining satisfactory quantities of proteins from natural sources in large amounts is typically laborious and expensive.

This technique has allowed the production of greater amounts of recombinant proteins per batch than traditional biotech methods, while also providing an increased level of control in the process. As cells multiply during the recombinant protein production process, potentially toxic genes can be produced through gradual mutations in DNA replication between generations. In order to prevent this, an off-state allows a halt to cell division before a potentially toxic gene is formed.

Pre-Clinical Validation

• 2.5x more recombinant protein than current biotech methods.
• Improved production lowers therapeutic proteins' production costs.
• Tight off state controls toxic genes. 

MacDonald, I Cody et al. “Enhanced regulation of prokaryotic gene expression by a eukaryotic transcriptional activator.” Nature communications vol. 12,1 4109. 5 Jul. 2021, doi:10.1038/s41467-021-24434-9

Aaron Duffy
(801) 585-1377
aaron.duffy@utah.edu