GYNECOLOGICAL-CANCER-PATIENT-DERIVED XENOGRAFTS

Endometrial cancer (EC) is the most common gynecological malignancy in the United States, with over 49,000 new cases each year. Current animal tumors have insufficient structural architecture and tumor heterogenity and lack of effective drugs hinders treatment of EC. This complicates tests performed to predict patient response to certain treatments.

A novel model for the development of highly personalized gynecological tumors has been created. Orthotopic implantation of tumors derived from patients with gynecological malignancies result in mouse models that simulate human oncogenesis over multiple generations. The model also provides an excellent model for translational studies.