Biofilm-related infections pose a significant challenge to healthcare providers as they form a barrier impermeable to antibiotics. As a result, treatment of these infections typically requires debridement, a task burdened by the invisibility of biofilm to the naked eye. Methylene blue (MB) is a compound safe to humans that is known to bind to and stain biofilms without staining healthy tissue or prosthetic implants. Yet, there is no easy way to apply MB to tissues.
University of Utah researchers have created an application device for methylene blue stain. The device can be used for convenient and precise application of MB in vivo, allowing healthcare providers to easily identify bacterial biofilm-infected tissue for removal.