COMBINATORIAL GENE CONSTRUCT AND NON-VIRAL DELIVERY FOR ANTI-OBESITY

Obesity is a risk factor for a variety of conditions, including diabetes, cancer, and heart disease. Single target protein therapies demonstrate poor efficacy as the body adapts quickly, activating alternate mechanisms to maintain its original state. Combinatorial approaches produce better results, but also greater side effects, leading to increased costs that limit patient compliance.
A novel combinatorial gene construct delivered using a non-viral vector demonstrates improved ability against obesity without significant side effects. The gene construct utilizes two genes that have key roles in the regulation of feeding inhibition, gastric emptying, and energy expenditure. These genes are administered with non-viral polymeric vector linear polyethylenimine, which is less toxic than other polymer vectors and not recognized by the immune system. The therapeutic efficiently transports DNA throughout the blood when administered weekly via intraperitoneal injections.