DIAGNOSTIC, PROGNOSTIC, AND THERAPEUTIC BIOMARKER FOR EWING’S SARCOMA

Ewing’s Sarcoma is an aggressive and highly metastatic bone or soft tissue associated tumor in children and young adults. These tumors frequently progress undetected until they metastasize, whereupon the mortality of the disease greatly increases. Many tumors develop resistance to current first-line treatments, yet no tool exists that distinguishes prior to treatment between resistant and sensitive tumors.

Glutathione-S-transferase M4 (GSTM4) has been identified as a major contributor to tumorigenesis and drug resistance in Ewing’s Sarcoma. Patients with higher levels of GSTM4 typically have worse treatment outcomes, meaning determination of GSTM4 expression levels should enable earlier diagnosis and serve as a predictor for patient outcomes. Furthermore, reduction of GSTM4 levels increases sensitivity of Ewing’s Sarcoma cells to chemotherapeutic agents and reduces oncogenic transformation.